An Incidence of β-Thalassemia in South India – A Review

-Thalassemia is one of the major genetic disorders which can be transmitted from parents to their children. In India, there is a concept of consanguineous marriage apart from having various castes and sub-castes in all the states. There are many ways of screening -Thalassemia. Complete hemogram like MCV, MCH, Hb values and the NESTROFT. The sample which shows positive for NESTROFT can be checked for HbA2 for confirmation using electrophoresis or HPLC. Eventually, we can check at molecular level the type of mutations present. Many researchers have utilized different methods for the screening of -Thalassemia. This article is an attempt to address some of the research work conducted in South India. Much more work is to be done in South India to know more about -Thalassemia and to bring awareness among the people.